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Diclofenac Sodium

发布时间:2020-09-04 09:46人气:


 
Diclofenac Sodium:

Characteristic: Pure white crystalline powder, slightly hygroscopic.

CAS Number: 15307-79-6

Molecular Formula: C14H10Cl2NNaO2

Certificate Of Analysis: BP2004 Edition

Properties : colorless crystalline powder. 283-285 ° C melting point, the free acid 156-158 ° C melting point.

Production methods : o-chlorotoluene as raw material, derived by the following steps.


Application : for the goods potent antipyretic analgesic anti-inflammatory drug. Its anti-inflammatory effect of indomethacin in a range of 2-2.5 times stronger than aspirin 26-50 times. In rheumatoid arthritis, osteoarthritis, post-operative pain and various causes of fever.

 

Item

Standard

Test Result

Characteristic

Pure white crystalline powder, slightly hygroscopic

Conforms

Solubility

Sparingly soluble in water, freely soluble in

Comforms

methanol, ethanol (96%); slightly soluble in acetone;

practically insoluble in ether

Identify

(A) IR-Spectrum

Aconforms

(B) Reaction of sodium salt

BPositive

PH

6.5~7.5

7.13

Appearance of solution

Clear

Conforms

Absorption of sodium salt≤0.05

0.015

Related substances

Single impurity ≤0.2%

Conforms

Total impurity ≤0.5%

Heavy metal

≤10ppm

Conforms

Loss on drying

≤0.5%

0.21%

Assay

99.0%101.0%

99.46%


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